Searchable abstracts of presentations at key conferences in endocrinology

ea0077p233 | Reproductive Endocrinology | SFEBES2021

In vitro effects of dihydrotestosterone (DHT) on gonadotropin receptor function and steroidogenesis in human granulosa lutein cells

Anujan Priyanka , Owens Lisa , Alro Botkjaer Jane , Hanyaloglu Aylin , Hardy Kate , Franks Stephen

Polycystic ovary syndrome (PCOS) is a multifactorial, complex endocrine disorder affecting a significant proportion of the global population. Hyperandrogenism is a key feature of PCOS patients. Aberrant secretion and/or action of gonadotropins have been implicated in PCOS, but, to date, we have only limited knowledge of how these factors may interact in the aetiology of PCOS. We hypothesised that excess androgens may cause aberrant gonadotropin activity and therefore sought to...